Table 3.

28-day mortality prediction in patients enrolled following either surgical or medical complaints

	Biomarker or clinical score	Patients (N)	Events (N)	AUROC	Univariate		Bivariate
					LR χ2	HR IQR [95% CI]	LR χ2	HR IQR [95% CI]
Surgical	MR-proADM	47	10	0.80 [0.66–0.94]	9.03	6.53 [1.65–25.88]	10.40	6.34 [1.84–41.04]
	PCT	47	10	0.47 [0.26–0.68]	0.34	1.39 [0.46–4.21]	0.68	1.56 [0.48–5.10]
	CRP	47	10	0.59 [0.38–0.79]	0.37	1.24 [0.60–2.58]	0.55	1.26 [0.60–2.63]
	Lactate	44	8	0.73 [0.49–0.97]	3.97	2.72 [1.00–7.39]	4.06	2.65 [0.98–7.20]
	APACHE II	29	7	0.53 [0.29–0.77]	0.01	1.05 [0.39–2.80]	0.78	0.86 [0.29–2.53]
	SOFA	47	10	0.74 [0.56–0.92]	10.86	5.05 [1.82–14.02]	11.12	5.55 [1.87–16.46]
Medical	MR-proADM	83	18	0.72 [0.57–0.87]	15.05	3.84 [1.96–7.54]	16.32	3.87 [1.90–7.86]
	PCT	80	18	0.55 [0.40–0.71]	0.10	0.89 [0.44–1.79[	2.89	0.90 [0.45–1.80]
	CRP	82	18	0.46 [0.30–0.61]	0.63	1.23 [0.71–2.15]	3.49	1.27 [0.70–2.29]
	Lactate	72	18	0.66 [0.51–0.82]	6.43	2.06 [1.21–3.51]	7.84	1.99 [1.14–3.46]
	APACHE II	35	7	0.59 [0.34–0.82]	0.20	1.28 [0.44–1.79]	0.43	1.17 [0.38–3.59]
	SOFA	83	18	0.71 [0.57–0.86]	16.32	3.87 [1.90–7.86]	13.33	2.50 [1.43–4.36]

APACHE II Acute Physiological and Chronic Health Evaluation II score, AUROC area under the receiver operating characteristic curve, CI confidence interval, CRP C-reactive protein, HR hazard ratio, IQR interquartile range, LR likelihood ratio of the χ² test, MR-proADM mid-regional proadrenomedullin, N number, PCT procalcitonin, SOFA Sequential Organ Failure Assessment score