Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 15;10:386. doi: 10.1038/s41598-019-57286-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

PC2 levels are increased in livers with NAFLD. (A) Plasma blood glucose levels and (B) quantified area under the curve during glucose tolerance tests of mice fed ND or HFD for 8 weeks. Shown are the mean area under the curve ± SD of 5 mice per group. **p < 0.01 as determined by Mann Whitney U test. (C) Mouse livers from ND- or HFD-fed mice were immunoblotted for PC2, 4-HNE, and CHOP. Each lane represents one biological replicate; sample size n = 4 per group. Full-length blots shown in Fig. S7. (D) Normalized mRNA expression of Pkd2 in livers of mice fed ND or HFD for 14 months. Gapdh used as internal control. Sample size n = 3 biological replicates per group. *p < 0.05 as determined by Mann Whitney U test. Data presented as median with range. (E) Normal human livers (NHL) or livers with non-alcoholic steatohepatitis (NASH) were stained for PC2 (green) and VDAC (red). Scale bar, 100 μm. LD = lipid droplet. Asterisks depict lipid accumulation within the liver. (F) PC2 intensity normalized to cell area was quantified in human NHK and NASH livers. ***p < 0.001 as determined Mann Whitney U test. Quantification is of 5 images per sample; sample number NHL n = 6, NASH n = 9.