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. 2019 Apr 26;52(1):10–23. doi: 10.4143/crt.2019.145

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Copyright © 2020 by the Korean Cancer Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — Cathepsin C (C TSC) promotes proliferation, migration, an d in vasion of hepatocellular carcinoma (HCC) cell lines. (A) The proliferation of SH-HEP-1 and SMMC-7721 cells infected with lentiviral LV-C TSC vector, or SK-HEP-1 and PLC/PRF/5 cells transfected with CTSC siRNA were assessed by Cell Counting Kit-8 assay. (B) The effects of CTSC on viability was assessed by colony formation assays. (C) Effects of overexpressing CTSC on tu morigenesis in vivo. (D) Trans-well chamber assays indicated the migratory ability of HCC cell lines. (E) Boyden chamber assays indicated thein vasiveness of HCC cell lines. *p < 0.05, **p < 0.01, ***p < 0.001.