Table 2.
Univariate and multivariate analysis of overall survival in HCC patients by Cox regression analysis
| Variable | Overall survival |
p-value | |
|---|---|---|---|
| HR | 95% CI | ||
| Univariate analysis | |||
| Age (> 50 yr vs. ≤ 50 yr) | 0.741 | 0.475-1.155 | 0.185 |
| Sex (male vs. female) | 1.624 | 0.705-3.738 | 0.254 |
| HBsAg (positive vs. negative) | 1.946 | 0.845-4.478 | 0.118 |
| Cirrhosis (present vs. absent) | 0.859 | 0.516-1.430 | 0.558 |
| Ascites (present vs. absent) | 1.960 | 1.076-3.570 | 0.028 |
| AFP (≥ 400 μg/L vs. < 400 μg/L) | 1.522 | 0.968-2.391 | 0.069 |
| Tumor size (> 5 cm vs. ≤ 5 cm) | 3.122 | 1.832-5.319 | < 0.001 |
| Tumor number (multiple vs. solitary) | 1.790 | 1.138-2.816 | 0.012 |
| Tumor capsule (incomplete vs. complete) | 2.415 | 1.543-3.780 | < 0.001 |
| PVTT (present vs. absent) | 2.751 | 1.676-4.514 | < 0.001 |
| Differentiation (Ⅲ-Ⅳ vs. Ⅰ-Ⅱ) | 1.427 | 0.823-2.473 | 0.206 |
| CTSC (high vs. low) | 1.770 | 1.127-2.779 | 0.013 |
| Multivariate analysis | |||
| Ascites | 0.067 | ||
| Tumor size (> 5 cm vs. ≤ 5 cm) | 3.264 | 1.905-5.593 | < 0.001 |
| Tumor number | 0.387 | ||
| Tumor capsule (incomplete vs. complete) | 3.028 | 1.886-4.860 | < 0.001 |
| PVTT | 0.057 | ||
| CTSC (high vs. low) | 2.402 | 1.493-3.865 | < 0.001 |
HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; HBsAg, hepatitis B virus surface antigen; AFP, α-fetoprotein; PVTT, portal vein tumor thrombus; CTSC, cathepsin C.