Fig. 6.

Metformin decreases pancreatic ductal adenocarcinoma (PDAC) incidence induced by a high-fat, high-calorie diet (HFCD) in KC mice by altering the expression of Clostridium sensu stricto. A: representative hematoxylin and eosin staining of the pancreas of KC mice fed on a control diet (left), HFCD (middle), or HFCD with metformin (right). B: percentage (%) of intact acini in KC mice by treatment groups. C: percentage (%) of pancreatic intraepithelial neoplasia (PanIN)-3 lesions in KC mice by treatment group. D: linear regression of Clostridium sensu stricto from luminal duodenal samples by percent intact acini. *P < 0.05. CD, control diet.