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. 2019 Oct 11;317(6):G773–G783. doi: 10.1152/ajpgi.00080.2019

Fig. 4.

Fig. 4.

Macrophage infiltration after bile duct ligation (BDL). A: F4/80 immunohistochemical staining. Macrophages accumulated to the necrotic area and periportal area in both wild-type (WT) mice and CXC chemokine receptor 2 knockout (CXCR2−/−; CXCR2KO) mice. Original magnification: ×200. B: macrophage polarization after BDL. IRF5 immunohistochemical staining showed that M1 macrophages preferably accumulated to the injured area in wild type. C: CD163 immunohistochemical staining showed that M2 macrophages existed in the sinusoid throughout liver tissue in wild type. CXCR2−/− mice also had similar pattern of the accumulation of M1 and M2 macrophages. Original magnification: ×200.