Fig. 2.

Patterns of plasma metabolites in overnight-fasted women during an acute exercise bout, using combined data from before and after a weight loss and training intervention. Results are illustrated as metabolite network clusters representing structural and biochemical similarity classes, with blue symbols indicating an exercise-associated reduction and orange symbols indicating an increased concentration during the first 15 min of exercise. Only annotated (known) metabolites are depicted. Circles outlined with a black line indicate metabolites with concentration changes that were statistically significant (mixed-effects model, P < 0.05), and node sizes convey the magnitude of change. Individual metabolite excursions may be found in Supplemental Figs. S1, A and B, and S2.