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Predicted transepithelial Na+ (TNa; A) and K+ (TK; B) fluxes in control rats and in rats at 14 days (D14) of angiotensin II treatment, with and without the observed downregulation of cortical Na+/H+ exchanger 3 (cNHE3) or activated medullary Na+-K+-2Cl− cotransporter-2 (mNKCC2-P). CCD, cortical collecting duct; CNT, connecting tubule; DCT, distal convoluted tubule; mTAL/cTAL, medullary/cortical thick ascending limb; OMCD/IMCD, outer/inner medullary collecting duct; PT, proximal tubule.
