Fig. 6.

Cl⁻ current does not depend on detrusor smooth muscle (DSM) cell capacitance (cell size). A and B: Cl⁻ currents (I) measured at the end of 100-ms voltage step from −100 to +130 mV plotted against DSM cell capacitance. The solid line represents a linear fit of data points with slope coefficient 2.1 pA/pF in control (A) and 6.6 pA/pF in the presence of 10 μM phosphatidylinositol 4,5-bisphosphate diC8 [PI(4,5)P₂-diC8] (B). Data obtained under control conditions (n = 59 cells, N = 19 guinea pigs) are shown in A. Data recorded with PI(4,5)P₂-diC8 added to the pipette solution (n = 57, N = 15) are shown in B.