Fig. 4.

Expression analysis of key target molecules in the retina of mice via Western blotting. The immunoblot data from the retinal lysates show decreased expression levels of tissue inhibitor of matrix metalloproteinase (TIMP)-1, and the component of the tight junction protein ZO-2 in the FVB/NJ when compared with MMP-9 KO and the C57BL/6J strains of the mice (A). The bar graphs show their quantitative estimations after normalization with the housekeeping GAPDH protein; the data are presented as means ± SE, *P < 0.05 when compared with C57BL/6J (B).