Table 4.
Serum concentration of selected proteins and clinical biochemical indices of study subjects
| Healthy Group (n = 103) |
HF Group (n = 75) |
ACS Group (n = 93) |
CCHD Group (n = 108) |
|
|---|---|---|---|---|
| TC, mmol/L | 4.71 ± 0.49 | 3.77 ± 0.98 | 4.66 ± 1.48 | 4.34 ± 1.21 |
| TG, mmol/L | 1.05 ± 0.36 | 1.21 ± 0.62 | 1.83 ± 1.28‡ | 1.64 ± 0.98† |
| HDL, mmol/L | 1.30 ± 0.19 | 0.99 ± 0.31‡ | 0.96 ± 0.26‡ | 1.00 ± 0.30‡ |
| LDL, mmol/L | 2.78 ± 0.39 | 2.35 ± 0.59 | 2.94 ± 1.11 | 2.71 ± 0.97 |
| AopA-1, g/L | 1.37 ± 0.31 | 1.04 ± 0.23‡ | 1.09 ± 0.23‡ | 1.13 ± 0.27‡ |
| ApoB, g/L | 0.82 ± 0.16 | 0.80 ± 0.25 | 0.90 ± 0.29 | 0.87 ± 0.30 |
| LPa, g/L | 0.11 (0.00,0.60) | 0.26 (0.02,1.22)* | 0.22 (0.01,1.22)† | 0.22 (0.00,1.12)† |
| HCY, μmol/L | 19.70 (8.60,184.00) | 22.60 (9.10,36.30)* | 17.15 (7.00,35.80) | 19.85 (0.00,38.50) |
| Myo, ng/mL | 26.62 (15.54,81.37) | 56.30 (0.00,576.39)‡ | 56.36 (25.74,1000.00)‡ | 50.71 (17.93,819.04)‡ |
| CTnI, ng/mL | 0.00 (0.00,0.04) | 0.07 (0.00,6.39)‡ | 3.79 (0.00,49.00)‡ | 0.02 (0.00,49.00)‡ |
| CK, U/L | 77 (6,912) | 84 (25,1243) | 168 (13,5573)‡ | 88 (2.88,2680)* |
| CK-MBm, ng/mL | 0.01 (0.00,1.58) | 1.61 (0.00,12.00)‡ | 2.18 (0.00,246.00)‡ | 1.04 (0.00,109.62)‡ |
| CK-MB, U/L | 11.00 (1.00,143.00) | 12.50 (4.00,35.00) | 20.50 (4.00,462.00)‡ | 14.00 (5.00,166.00) |
| CRP, mg/L | 0.65 (0.01,257.00) | 11.90 (0.09,120.70)‡ | 5.03 (0.20,178.70)‡ | 1.90 (0.08,156.10)‡ |
| LDH, U/L | 190 (80,365) | 240.50 (0,790)† | 265 (127,1111)‡ | 168 (77,1181) |
| AST, U/L | 22 (16,105) | 30 (9,242) | 35.5 (10,343)† | 21 (10,1104) |
| SPP1, ng/mL | 1.50 (0.18,9.08) | 19.17 (0.12,70.88)† | 22.87 (0.55,120.20)‡ | 4.90 (0.23,226.99) |
| MMP7, ng/mL | 5.06 (0.32,19.85) | 2.06 (0.32,7.16) | 5.69 (0.32,15.24) | 2.06 (0.32.104.00) |
| TREM1, pg/mL | 104.47 (63.69,324.78) | 129.88 (86.42,351.10) | 119.89 (55.16,920.45) | 115.07 (56.34,9888.96) |
| S100A9, pg/mL | 1086.08 (716.48,1679.37) | 1071.11 (504.91,4381.86) | 1045.59 (590.85,3103.03) | 1086.13 (590.85,28213.91) |
| CD36, ng/mL | 1902.45 ± 962.81 | 2037.25 ± 1445.03 | 4065.74 ± 2845.85† | 3382.15 ± 1820.44 † |
| TM4SF19, pg/mL | 56.19 (43.37,216.89) | 80.50 (46.79,169.68) | 89.61 (43.50,7660.00) | 116.70 (42.28,375.93) |
| FABP5, ng/mL | 1.20 ± 0.50 | 1.06 ± 0.33 | 1.23 ± 0.68 | 1.00 ± 0.58 |
| ATP6V0D2, ng/mL | 11.32 ± 1.08 | 14.45 ± 1.10* | 13.44 ± 1.68† | 13.00 ± 2.92* |
| CXCR4, pg/mL | 178.26 (75.41,599.89) | 164.62 (89.71,882.16) | 184.72 (52.30,845.48) | 205.41 (40.34,3623.1) |
| CHI3L1, ng/mL | 32.94 ± 8.44 | 50.81 ± 14.35* | 67.48 ± 28.53‡ | 52.80 ± 27.93† |
| MYOCD, nmol/mL | 4.94 ± 0.38 | 6.01 ± 1.35 | 4.17 ± 0.57 | 4.55 ± 0.39 |
| SCARA3, ng/mL | 0.58 (0.41,2.15) | 0.81 (0.47,1.79) | 0.67 (0.001,15.75) | 1.05 (0.34,5.50) |
| FIBIN, ng/mL | 8.33 (6.43,25.59) | 9.49 (6.14,15.46) | 10.99 (5.64,2030.08) | 10.28 (6.09,26.10) |
| TRIM36, ng/mL | 1.78 ± 0.37 | 1.61 ± 0.28 | 1.87 ± 0.84 | 1.88 ± 0.36 |
| ACADL, ng/mL | 18.60 (11.09,56.06) | 13.30 (10.36,20.54) | 17.06 (8.52,35.10) | 13.66 (6.08,142.10) |
| IGFBPL1, ng/mL | 1.69 (0.70,2.94) | 2.75 (0.92,13.32) | 2.06 (0.64,11.47) | 1.48 (0.70,7.38) |
| MYH11, pg/mL | 341.57 (239.47,1786.18) | 666.46 (481.04,1559.76)‡ | 617.55 (305.71,6767.05)‡ | 823.25 (288.47,8571.14)‡ |
| TTLL7, ng/mL | 0.95 (0.45,4.00) | 1.24 (0.42,2.52) | 1.55 (0.45,3.69) | 1.41 (0.48,3.76) |
| BDNF, pg/mL | 4308.07 ± 903.54 | 2939.72 ± 955.59* | 3066.50 ± 1260.44† | 3193.47 ± 1091.37† |
| MYLK, ng/mL | 55.55 (4.86,289.35) | 66.17 (28.79,230.54) | 70.94 (18.34,402.53) | 76.67 (14.25,314.84) |
| TC, mmol/L | 4.71 ± 0.49 | 3.77 ± 0.98 | 4.66 ± 1.48 | 4.34 ± 1.21 |
| TG, mmol/L | 1.05 ± 0.36 | 1.21 ± 0.62 | 1.83 ± 1.28‡ | 1.64 ± 0.98† |
| HDL, mmol/L | 1.30 ± 0.19 | 0.99 ± 0.31‡ | 0.96 ± 0.26‡ | 1.00 ± 0.30‡ |
| LDL, mmol/L | 2.78 ± 0.39 | 2.35 ± 0.59 | 2.94 ± 1.11 | 2.71 ± 0.97 |
| AopA-1, g/L | 1.37 ± 0.31 | 1.04 ± 0.23‡ | 1.09 ± 0.23‡ | 1.13 ± 0.27‡ |
| ApoB, g/L | 0.82 ± 0.16 | 0.80 ± 0.25 | 0.90 ± 0.29 | 0.87 ± 0.30 |
| LPa, g/L | 0.11 (0.00,0.60) | 0.26 (0.02,1.22)* | 0.22 (0.01,1.22)† | 0.22 (0.00,1.12)† |
| HCY, μmol/L | 19.70 (8.60,184.00) | 22.60 (9.10,36.30)* | 17.15 (7.00,35.80) | 19.85 (0.00,38.50) |
| Myo, ng/mL | 26.62 (15.54,81.37) | 56.30 (0.00,576.39)‡ | 56.36 (25.74,1000.00)‡ | 50.71 (17.93,819.04)‡ |
| CTnI, ng/mL | 0.00 (0.00,0.04) | 0.07 (0.00,6.39)‡ | 3.79 (0.00,49.00)‡ | 0.02 (0.00,49.00)‡ |
| CK, U/L | 77 (6,912) | 84 (25,1243) | 168 (13,5573)‡ | 88 (2.88,2680)* |
| CK-MBm, ng/mL | 0.01 (0.00,1.58) | 1.61 (0.00,12.00)‡ | 2.18 (0.00,246.00)‡ | 1.04 (0.00,109.62)‡ |
| CK-MB, U/L | 11.00 (1.00,143.00) | 12.50 (4.00,35.00) | 20.50 (4.00,462.00)‡ | 14.00 (5.00,166.00) |
| CRP, mg/L | 0.65 (0.01,257.00) | 11.90 (0.09,120.70)‡ | 5.03 (0.20,178.70)‡ | 1.90 (0.08,156.10)‡ |
| LDH, U/L | 190 (80,365) | 240.50 (0,790)† | 265 (127,1111)‡ | 168 (77,1181) |
| AST, U/L | 22 (16,105) | 30 (9,242) | 35.5 (10,343)† | 21 (10,1104) |
| SPP1, ng/mL | 1.50 (0.18,9.08) | 19.17 (0.12,70.88)† | 22.87 (0.55,120.20)‡ | 4.90 (0.23,226.99) |
| MMP7, ng/mL | 5.06 (0.32,19.85) | 2.06 (0.32,7.16) | 5.69 (0.32,15.24) | 2.06 (0.32.104.00) |
| TREM1, pg/mL | 104.47 (63.69,324.78) | 129.88 (86.42,351.10) | 119.89 (55.16,920.45) | 115.07 (56.34,9888.96) |
| S100A9, pg/mL | 1086.08 (716.48,1679.37) | 1071.11 (504.91,4381.86) | 1045.59 (590.85,3103.03) | 1086.13 (590.85,28213.91) |
| CD36, ng/mL | 1902.45 ± 962.81 | 2037.25 ± 1445.03 | 4065.74 ± 2845.85† | 3382.15 ± 1820.44 † |
| TM4SF19, pg/mL | 56.19 (43.37,216.89) | 80.50 (46.79,169.68) | 89.61 (43.50,7660.00) | 116.70 (42.28,375.93) |
| FABP5, ng/mL | 1.20 ± 0.50 | 1.06 ± 0.33 | 1.23 ± 0.68 | 1.00 ± 0.58 |
| ATP6V0D2, ng/mL | 11.32 ± 1.08 | 14.45 ± 1.10* | 13.44 ± 1.68† | 13.00 ± 2.92* |
| CXCR4, pg/mL | 178.26 (75.41,599.89) | 164.62 (89.71,882.16) | 184.72 (52.30,845.48) | 205.41 (40.34,3623.1) |
| CHI3L1, ng/mL | 32.94 ± 8.44 | 50.81 ± 14.35* | 67.48 ± 28.53‡ | 52.80 ± 27.93† |
| MYOCD, nmol/mL | 4.94 ± 0.38 | 6.01 ± 1.35 | 4.17 ± 0.57 | 4.55 ± 0.39 |
| SCARA3, ng/mL | 0.58 (0.41,2.15) | 0.81 (0.47,1.79) | 0.67 (0.001,15.75) | 1.05 (0.34,5.50) |
| FIBIN, ng/mL | 8.33 (6.43,25.59) | 9.49 (6.14,15.46) | 10.99 (5.64,2030.08) | 10.28 (6.09,26.10) |
| TRIM36, ng/mL | 1.78 ± 0.37 | 1.61 ± 0.28 | 1.87 ± 0.84 | 1.88 ± 0.36 |
| ACADL, ng/mL | 18.60 (11.09,56.06) | 13.30 (10.36,20.54) | 17.06 (8.52,35.10) | 13.66 (6.08,142.10) |
| IGFBPL1, ng/mL | 1.69 (0.70,2.94) | 2.75 (0.92,13.32) | 2.06 (0.64,11.47) | 1.48 (0.70,7.38) |
| MYH11, pg/mL | 341.57 (239.47,1786.18) | 666.46 (481.04,1559.76)‡ | 617.55 (305.71,6767.05)‡ | 823.25 (288.47,8571.14)‡ |
| TTLL7, ng/mL | 0.95 (0.45,4.00) | 1.24 (0.42,2.52) | 1.55 (0.45,3.69) | 1.41 (0.48,3.76) |
| BDNF, pg/mL | 4308.07 ± 903.54 | 2939.72 ± 955.59* | 3066.50 ± 1260.44† | 3193.47 ± 1091.37† |
| MYLK, ng/mL | 55.55 (4.86,289.35) | 66.17 (28.79,230.54) | 70.94 (18.34,402.53) | 76.67 (14.25,314.84) |
Data are presented as means ± SD or medians (interquartile range) unless otherwise indicated. ACS, acute coronary syndrome; CCHD, chronic coronary heart disease; HF, heart failure. Compared with healthy group:
*
P < 0.05;
†
P < 0.01;
‡
P < 0.001.