Fig. 5.

RTD-1-responsive PIA disease genes. A: two-way hierarchical clustering of the 107 genes regulated by 5-day treatment with RTD-1 across all treatment cohorts shows similar patterns of genes in synovium of 5-day peptide treatment group and that of naive animals. B: gene enrichment of differentially expressed genes in PIA after 3 days and 5 days of RTD-1 treatment. Each enriched pathway is ranked based on the P value computed from the Fisher exact test based on the binomial distribution and independence for probability of any gene belonging to any enriched set. Source databases are shown in parentheses. C: plots of Z scores of common upstream regulators predicted by IPA in untreated PIA and in PIA following 5-day RTD-1 treatment show the homeostatic effects of peptide treatment on arthritis associated pathways.