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Histology of lung tissues in ORFeusLSL mice treated with benzo(a)pyrene (BaP) alone or in combination with CRE recombinase. A–I: representative results for all treatment groups at ×20. Blue arrows indicate the pulmonary edema evidenced by vascular dilation, black arrows denote pulmonary vessel congestion, and the red arrow denotes emphysematous changes evidenced by large empty spaces with variable preservation of alveolar structures. Here, n = 3 animals examined.
