Table 1.
DNA adduct signal intensity in the lungs of ORFeusLSL mice following treatment with benzo(a)pyrene alone or in combination with CRE recombinase
| Relative Adduct Labeling |
||||||
|---|---|---|---|---|---|---|
| Treatment | Adduct 1 | Adduct 2 | Adduct 3 | Adduct 4 | Adduct 5 | Total |
| Untreated control | 3.50 ± 1.91f | 1.69 ± 0.88n,o | 2.71 ± 1.65j | 1.39 ± 0.62q | 1.68 ± 0.34n,o | 2.19 ± 0.82E |
| CRE-DMSO | 2.82 ± 1.95i | 1.71 ± 1.23n | 1.92 ± 0.80m | 0.84 ± 0.35u,v | 1.18 ± 0.29s | 1.69 ± 0.70F |
| BaP (F) | 28.01 ± 17.49a | 2.95 ± 0.99h | 4.04 ± 1.74e | 1.44 ± 0.65p,q | 1.40 ± 0.83q | 7.57 ± 10.92A |
| BaP (M) | 10.35 ± 6.21d | 1.65 ± 0.30o | 1.48 ± 0.78p | 0.66 ± 0.23w | 1.25 ± 0.43r | 3.08 ± 3.78D |
| Cre-BaP (F) | 23.86 ± 3.99b | 2.39 ± 0.87k | 3.10 ± 0.66g | 0.89 ± 0.16u | 1.30 ± 0.55r | 6.31 ± 9.12B |
| Cre-BaP (M) | 17.61 ± 9.34c | 1.94 ± 0.35m | 2.29 ± 0.51l | 0.80 ± 0.28v | 1.05 ± 0.72t | 4.73 ± 6.68C |
| Total | 14.36 ± 9.89A | 2.06 ± 0.48B | 2.59 ± 0.86B | 1.0 ± 0.30C | 1.31 ± 0.22C | |
Values are means ± SD; n = 3 animals examined. Relative adduct labeling is equal to the number of adducts per 108 nucleotides. BaP, benzo(a)pyrene; F, female; M, male.
a–w, A–FSignificant differences between and among the different groups by sex × treatment.