Table 1.

Demographics and resting arterial blood samples and pressure

	Control (n = 12)	High-Affinity Hb (n = 9)
Sex	6M:6F	3M:6F
Age, yr	41 ± 3	43 ± 4
Mass, kg	82 ± 4	91 ± 10
Height, cm	174 ± 3	164 ± 3*
BMI, kg m2	27.0 ± 1.0	33.8 ± 3.7
P50, mmHg	26 ± 0.4	16 ± 0.4*
$\text{P}{\text{a}}_{\text{O}}{}_{{}_2}$, mmHg	89 ± 2	87 ± 2
$\text{P}{\text{a}}_{\text{C}\text{O}}{}_{{}_2}$, mmHg	40 ± 1	39 ± 1
pH	7.41 ± 0.003	7.41 ± 0.004
cBase, mmol/L	0.5 ± 0.5	−0.01 ± 0.5
${\text{HCO}}_3^{-}$, mmol/L	25 ± 0.5	25 ± 0.5
Lac, mmol/L	0.6 ± 0.1	0.6 ± 0.0
Hb, g/dL	13.7 ± 0.3	19.0 ± 0.6*
$\text{S}{\text{a}}_{{\text{O}}_2}$, %)/	96 ± 0.1	97 ± 0.2*
$\text{C}{\text{a}}_{\text{O}}{}_{{}_2}$, ml dL−1	17.8 ± 0.4	25.0 ± 0.9*
MAP, mmHg	109 ± 4	107 ± 3
Heart rate, beats/min	60 ± 4	77 ± 4*
‡Stroke volume, ml	74 ± 6	71 ± 7
‡Cardiac output, L/min	4.2 ± 0.2	5.5 ± 1.5*

Values are means ± SE. BMI, body mass index; MAP, mean arterial pressure; P₅₀, pressure at which 50% of hemoglobin is saturated with oxygen; $\text{P}{\text{a}}_{\text{O}}{}_{{}_2}$, arterial oxygen tension; $\text{P}{\text{a}}_{\text{C}\text{O}}{}_{{}_2}$, arterial carbon dioxide tension; cBase, base excess concentration; Lac, arterial lactate concentration; Hb, hemoglobin concentration; $\text{S}{\text{a}}_{{\text{O}}_2}$, arterial oxyhemoglobin saturation; $\text{C}{\text{a}}_{\text{O}}{}_{{}_2}$, arterial oxygen content.

^*P < 0.05, significantly different from control.

^‡Cardiac output and stroke volume were derived from echocardiography in n = 5 high affinity hemoglobin and n = 11 controls.