Fig. 1.

Increased arrhythmia occurrence in db/db mice. A: exemplary image of the ex vivo Langendorff setup, including the octapolar catheter positioned in the right atrium and right ventricle as well as the epicardial multielectrode array (MEA). B: exemplary tracing of arrhythmia induction by using burst stimulation. In the upper tracing, no ventricular arrhythmia occurred in control mice in comparison to the lower tracing, in which a self-terminating arrhythmia could be induced in db/db mice. C: arrhythmia occurrence (i), number of ventricular tachycardias per heart (ii), and the arrhythmia score (iii) upon programmed stimulation were increased in db/db mice. Control: n = 12 mice; db/db: n = 12 mice. **P ≤ 0.05; ***P ≤ 0.003.