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. 2019 Sep 25;317(6):R803–R813. doi: 10.1152/ajpregu.00218.2019

Fig. 8.

Fig. 8.

Effect of MK2206 on hypoxia/ischemia (HI)-induced brain infarct size in both nicotine-exposed and saline control offspring. MK2206 or vehicle was administered intracerebraoventricularly to perinatal nicotine-exposed and saline control offspring on postnatal day 8. After 24 h of treatment, pups were exposed to HI procedures. Then, HI-induced brain infarct size with/without treatment of MK2206 was measured by triphenyltetrazolium chloride monohydrate (TTC) staining 48 h after HI procedures. Top: images represent HI-induced brain infarct size determined by 2% TTC staining. Summed infarct sizes, expressed as precent total brain weight, are shown at bottom. Data are means ± SE of animals (n = 8–11) from each group. Data were analyzed by 2-way ANOVA. *P < 0.05 vs. saline control.