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. 2019 Dec 26;14(1):21–33. doi: 10.1016/j.stemcr.2019.11.008

Figure 2.

Figure 2

Vasculogenesis-Disabled Phenotype of KDR−/– Fetus and Its Compensation by Blastocyst Complementation

(A) A PDX1/KDR dual KO (DKO) fetus with vasculogenesis-disabled phenotype (left) and a chimeric fetus with normalized trait (right) obtained after blastocyst complementation.

(B) Left: a PDX1/KDR-KO fetus showing retarded development without blood flow. Center: the appearance of a chimeric fetus showing systemic chimerism with dense distribution of the exogenous huKO-expressing cells. Right: morphology and fluorescence intensity of a normal fetus derived from the huKO transgenic cell. Scale bars, 1 mm.

See also Figure S2.