Figure 9.

DNAzymes Catalyzing Other Reactions

(A) The two DNAzymes can accelerate the porphyrin metalation reaction (T30695 requires Pb²⁺).

(B) The structure of iron (III)-protoporphyrin IX (hemin).

(C) A G4 DNAzyme/hemin complex catalyzing the oxidation of ABTS in the presence of H₂O₂ into ABTS^·+.

(D) Oxidative DNA cleavage catalyzed by DNA with the potential cleavage sites marked by dashed lines.

(E–G) (E) Hydrolytic DNA cleavage catalyzed by the I-R3 DNAzyme. RNA ligation reaction catalyzed by DNAzymes resulting in either (F) a linear 3′-5′ linkage or (G) a 2′,5′-branched linkage.

(H) Phosphatase activity of the 14WM9 DNAzyme.

(I) DNA-catalyzed nucleopeptide bond formation between a Tyr side chain and a 5′-triphosphorylated RNA.