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. 2020 Jan 9;6:147. doi: 10.3389/fmolb.2019.00147

Figure 1.

Figure 1

The expression of Txnip is significantly positively correlated with the intracellular glucose levels. (A,B) mRNA level of Txnip expressed in the human breast cancer Bcap37 and HeLa cell lines at the indicated glucose concentrations (T-test, *P < 0.05; **P < 0.01; ***P < 0.001); (A) Bcap37; (B) HeLa; (C,D) protein level of Txnip expressed in the human breast cancer Bcap37 and HeLa cell lines at the indicated glucose concentrations; (C) Bcap37; (D) HeLa; (E) quantification of Txnip protein expression level at the indicated glucose concentrations in Bcap37 and HeLa (T-test, *P < 0.05; **P < 0.01; ***P < 0.001); (F) protein levels of Txnip expressed by the mouse breast cancer 4T1 cell line at the indicated glucose concentrations with or without MG132; (G) quantification of Txnip protein expression level at the indicated glucose concentrations in 4T1 (T-test, *P < 0.05; **P < 0.01; ***P < 0.001); (H) double luciferase reporter gene test of the binding efficiency of MondoA to the Txnip promoter at different glucose conditions (T-test, *P < 0.05; **P < 0.01; ***P < 0.001); (I) Txnip expression on the condition of knockdown MondoA and Mlx.