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Several key point mutations of MondoA have decreased occupation on the Txnip promoter. (A) The distribution of wild type (WT) and mutant (139-141 mut) MondoA in the cell w/o 2DG stimulation; (B) Nuclear separation with regard to the distribution; (C) The binding efficiency of wild-type (WT) and mutant (139-141 mut) Mondo A in the EMSA (gel shift) test.
