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The binding rate of the wild-type and mutant MondoAs to the downstream gene promoter are different (A–C) (T-test, *P < 0.05; **P < 0.01; ***P < 0.001) and so is the expression level of Txnip protein. (A) The binding rate of MondoAs to the Txnip promoter E-box; (B) the binding rate to the hHkII promoter E-box; (C) the binding rate to Ng (negative control); (D) Txnip protein expression after WT or mutant plasmid overexpression.
