Table 2.
The associations of p16/Ki-67, p16/mcm2 expression and HR-HPV infection, N (%)
| Biomarkers | HR-HPV negative | Other 12 HR-HPV positive | HPV16/18 positive |
|---|---|---|---|
| p16/Ki67 | |||
| + | 13 (12.1) | 30 (38.5) | 9 (69.2) |
| - | 94 (87.9) | 48 (61.5) | 4 (30.8) |
| P value | - | <0.001 | <0.001 |
| OR (95% CI) | Ref. | 4.52 (2.16-9.45) | 16.27 (4.38-60.47) |
| p16/mcm2 | |||
| + | 16 (15.0) | 48 (61.5) | 11 (84.6) |
| - | 91 (85.0) | 30 (38.5) | 2 (15.4) |
| P value | - | <0.001 | <0.001 |
| OR (95% CI) | Ref. | 9.10 (4.52-18.33) | 31.28 (6.33-154.56) |
Abbreviations: OR, odds ratio; CI, confidence interval; Other 12 HR-HPV positive: positive for any of the 12 HPV types (HPV 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68), and negative for HPV16/18; Ref, reference.