Table 3.
Clinical performance characteristics of p16/Ki-67, p16/mcm2, LBC and HPV16/18 genotyping for detection of CIN2+ and CIN3+ at baseline, % (95% CI)
| Methods | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| CIN2+ | ||||
| p16/Ki-67 | 94.1 (73.0-99.0) | 80.1 (73.7-85.3) | 30.8 (19.9-44.3) | 99.3 (96.2-99.9) |
| p16/mcm2 | 88.2 (65.7-96.7) | 66.9 (59.7-73.3) | 20.0 (12.5-30.4) | 98.4 (94.3-99.6) |
| LBC | 47.1 (26.2-69.0) | 91.7 (86.8-94.9) | 34.8 (18.8-55.1) | 94.9 (90.5-97.3) |
| HPV16/18 | 29.4 (13.3-53.1) | 95.6 (91.5-97.7) | 38.5 (17.7-64.5) | 93.5 (89.0-96.3) |
| CIN3+ | ||||
| p16/Ki-67 | 92.9 (68.5-98.7) | 78.8 (72.3-84.1) | 25.0 (15.2-38.2) | 99.3 (96.2-99.9) |
| p16/mcm2 | 85.7 (60.1-96.0) | 65.8 (58.7-72.2) | 16.0 (9.4-25.9) | 98.4 (94.3-99.6) |
| LBC | 57.1 (32.6-78.6) | 91.9 (87.0-95.0) | 35.8 (18.8-55.1) | 96.6 (92.7-98.4) |
| HPV16/18 | 35.7 (16.3-61.2) | 95.7 (91.7-97.8) | 38.5 (17.7-64.5) | 95.1 (91.0-97.4) |
Abbreviations: CIN2+, cervical intraepithelial neoplasia grade 2 or worse; CIN3+, cervical intraepithelial neoplasia grade 3 or worse; LBC, liquid-based cytology; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.