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LncRNA XIST knockdown inhibits Aβ25-35-induced oxidative stress and apoptosis in hippocampal neurons. Hippocampal neurons were treated with control, 25 μM Aβ25-35, si-control+25 μM Aβ25-35, and si-XIST+25 μM Aβ25-35. Then the activities of SOD (A) and GSH-Px (B), MDA level (C), the number of TUNEL-positive neurons (D), and the protein expression of Bax, Bcl-2, caspase-3 activity and cytochrome c release (E) were determined. *P < 0.05.
