Figure 5.
miR-132 inhibits the toxicity, oxidative stress and apoptosis caused by Aβ25-35 treatment in hippocampal neurons. Hippocampal neurons were treated with control, 25 μM Aβ25-35, miR-control+25 μM Aβ25-35, and miR-132 mimic+25 μM Aβ25-35. Then the morphologic observation (A), cell viability (B), LDH release (C), K+ leakage (D), activities of SOD (E) and GSH-Px (F), MDA level (G), the number of TUNEL-positive neurons (H), and the protein expression of Bax, Bcl-2, caspase-3 activity and cytochrome c release (I) were determined. *P < 0.05.