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. 2018 Jul 1;11(7):3247–3256.

Figure 3.

Figure 3

(A) NaHS downregulates the expression of cleaved caspase-3, caspase-9, caspase-12, and Bax and upregulates the expression of Bcl-2 in EC109 cells. EC109 cells were treated with NaHS (500 µmol/L) for 6, 12, and 24 h. AG490 upregulates the NaHS-induced decreased in the expression of cleaved caspase-3, caspase-9, caspase-12 and Bax (B-F) and inhibits the NaHS-induced increase in the expression of Bcl-2 in EC109 cells (E). EC109 cells were co-treated with NaHS (500 µmol/L) and AG490 (60 µmol/L) for 24 h. The expressions of cleaved caspase-3, caspase-9, caspase-12, Bax, and Bcl-2 were measured by western blot analysis followed by densitometric analysis. Data are presented as the mean ± SEM (n=3). **P<0.01 versus control group; ++P<0.01 versus NaHS group.