Table 2.
Correlation between Wnt7a expression and various factors in colorectal adenocarcinoma (n = 393)
| Factors | n | Expression of Wnt7a | |||
|---|---|---|---|---|---|
|
| |||||
| Negative (%) (n = 156) | Positive (%) (n = 237) | p value | rs | ||
| Age (years) | |||||
| Median (IQR) | 393 | 64 (71-58) | 65 (72-57) | 0.560† | 0.029 |
| Gender | |||||
| Male | 242 | 99 (40.9) | 143 (59.1) | 0.533‡ | 0.031 |
| Female | 151 | 57 (37.7) | 94 (62.3) | ||
| Tumor location | |||||
| Colon | 251 | 97 (38.6) | 154 (61.4) | 0.572‡ | -0.029 |
| Rectum | 142 | 59 (41.5) | 83 (58.5) | ||
| Tumor size | |||||
| Median (IQR) | 393 | 5.0 (6.5-4.0) | 4.5 (6.0-3.0) | 0.026† | -0.113 |
| Gross type | |||||
| Polypoid | 46 | 12 (26.1) | 34 (73.9) | 0.008* | -0.132 |
| Ulcerofungating | 154 | 56 (36.4) | 98 (63.6) | ||
| Ulceroinfiltrative | 193 | 88 (45.6) | 105 (54.4) | ||
| Tumor subtype | |||||
| Tubular | 366 | 141 (38.5) | 225 (61.5) | 0.081‡ | -0.088 |
| Mucinous | 27 | 15 (55.6) | 12 (44.4) | ||
| Differentiation | |||||
| Well | 26 | 6 (23.1) | 20 (76.9) | 0.009* | -0.129 |
| Moderately | 186 | 67 (36.0) | 119 (64.0) | ||
| Poorly | 181 | 83 (45.9) | 98 (54.1) | ||
| Tumor budding | |||||
| Low-grade | 238 | 91 (38.2) | 147 (61.8) | 0.464‡ | -0.037 |
| High-grade | 155 | 65 (41.9) | 90 (58.1) | ||
| Vascular invasion | |||||
| Absent | 315 | 117 (37.1) | 198 (62.9) | 0.038‡ | -0.105 |
| Present | 78 | 39 (50.0) | 39 (50.0) | ||
| Perineural invasion | |||||
| Absent | 198 | 70 (35.4) | 128 (64.6) | 0.076‡ | -0.089 |
| Present | 195 | 86 (44.1) | 109 (55.9) | ||
| Tumor deposits | |||||
| Absent | 318 | 116 (36.5) | 202 (63.5) | 0.007‡ | -0.135 |
| Present | 75 | 40 (53.3) | 35 (46.7) | ||
| PNTE¶ | |||||
| Absent | 119 | 57 (47.9) | 62 (52.1) | 0.894‡ | 0.009 |
| Present | 100 | 47 (47.0) | 53 (53.0) | ||
| T category | |||||
| T1 | 32 | 6 (18.8) | 26 (81.3) | 0.003* | -0.135 |
| T2 | 39 | 11 (28.2) | 28 (71.8) | ||
| T3 | 245 | 104 (42.4) | 141 (57.6) | ||
| T4 | 77 | 35 (45.5) | 42 (54.5) | ||
| N category | |||||
| N0 | 174 | 52 (29.9) | 122 (70.1) | < 0.001‡ | -0.179 |
| N1, N2 | 219 | 104 (47.5) | 115 (52.5) | ||
| M category | |||||
| M0 | 366 | 142 (38.8) | 224 (61.2) | 0.181‡ | -0.067 |
| M1 | 27 | 14 (51.9) | 13 (48.1) | ||
| AJCC stage | |||||
| I | 53 | 10 (18.9) | 43 (81.1) | < 0.001* | -0.208 |
| II | 119 | 40 (33.6) | 79 (66.4) | ||
| III | 194 | 92 (47.4) | 102 (52.6) | ||
| IV | 27 | 14 (51.9) | 13 (48.1) | ||
†
Mann-Whitney U test;
‡
Chi-square test for independence;
*
Chi-square test for linear trend.
SD: standard deviation; IQR: interquartile range; PNTE: perinodal tumor extension; AJCC: American Joint Committee on Cancer; rs: Spearman’s rank correlation coefficient.
¶
Cases without lymph node metastasis (N0 cases; n = 174) have been excluded.