Table 3.
Univariate and multivariate analysis of OS
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
|
| ||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Gender | ||||
| Female | 1 | |||
| Male | 1.225 (0.850-1.766) | 0.277 | ||
| Age (years) | ||||
| <65 | 1 | |||
| ≥65 | 1.148 (0.798-1.649) | 0.457 | ||
| Location | ||||
| Colon | 1 | |||
| Rectum | 1.077 (0.727-1.959) | 0.710 | ||
| Size (cm) | ||||
| <5 | 1 | |||
| ≥5 | 1.345 (0.918-1.972) | 0.129 | ||
| T stage | ||||
| T1+T2 | 1 | |||
| T3+T4 | 1.347 (0.880-2.060) | 0.17 | ||
| N stage | ||||
| N0 | 1 | |||
| N1+N2 | 1.156 (0.801-1.669) | 0.438 | ||
| M stage | ||||
| M0 | 1 | 1 | ||
| M1 | 2.154 (1.420-3.267) | <0.001* | 1.629 (0.988-2.686) | 0.056 |
| AJCC stage | ||||
| I+II | 1 | 1 | ||
| III+IV | 1.504 (1.044-2.169) | 0.029* | 1.004 (0.650-1.552) | 0.984 |
| Differentiation | ||||
| Well + Moderate | 1 | |||
| Poor | 1.159 (0.740-1.815) | 0.520 | ||
| Ki67 (negative vs positive) | 1.610 (1.109-2.335) | 0.012* | 1.032 (0.614-1.736) | 0.905 |
| N-cadherin (negative vs positive) | 1.576 (1.060-2.342) | 0.025* | 1.103 (0.660-1.842) | 0.708 |
| FBXO2 (negative vs positive) | 2.496 (1.644-3.790) | <0.001* | 1.817 (1.106-2.983) | 0.018* |
| Combined (negative vs positive) | 3.025 (2.070-4.421) | <0.001* | 1.913 (0.964-3.796) | 0.063 |
*
P<0.05.