Table 6.
Correlation of Gli1 expression with PI3K/Akt/NF-ΚB signaling in prostate cancer
| Variable | N | Gli1 (-) n (%) | Gli1 (+) n (%) | χ2 | R | P-value |
|---|---|---|---|---|---|---|
| pPI3K p85 | 13.720 | 0.306 | <0.001* | |||
| Negative | 71 | 46 (64.8) | 25 (35.2) | |||
| Positive | 74 | 24 (32.4) | 50 (67.6) | |||
| pAkt-Ser473 | 11.319 | 0.288 | 0.001* | |||
| Negative | 31 | 23 (74.2) | 8 (25.8) | |||
| Positive | 114 | 47 (41.2) | 67 (58.8) | |||
| pAkt-Thr308 | 0.693 | 0.071 | 0.405 | |||
| Negative | 10 | 3 (30.0) | 7 (70.0) | |||
| Positive | 135 | 67 (49.6) | 68 (50.4) | |||
| NF-ΚB p65 | 24.204 | 0.409 | <0.001* | |||
| Negative | 54 | 40 (74.1) | 14 (25.9) | |||
| Positive | 91 | 30 (33.0) | 61 (67.0) |
*
Statistically significant.