Table 5.
Cox’s proportional hazards regression model analysis of factors affecting OS
| Parameters | Univariate Cox’s regression | Multivariate Cox’s regression | ||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| P value | HR | 95% CI | P value | HR | 95% CI | |||
|
|
|
|||||||
| Lower | Higher | Lower | Higher | |||||
| Integrin-α7 high expression | <0.001 | 3.869 | 2.542 | 5.890 | <0.001 | 2.721 | 1.702 | 4.350 |
| Age (≥65 years) | 0.437 | 1.177 | 0.780 | 1.778 | 0.874 | 1.047 | 0.591 | 1.855 |
| Gender (male) | 0.152 | 1.351 | 0.895 | 2.040 | 0.671 | 1.110 | 0.686 | 1.798 |
| Higher pathological grade | 0.096 | 1.412 | 0.940 | 2.122 | 0.041 | 1.640 | 1.019 | 2.637 |
| Largest tumor size (≥5 cm) | 0.013 | 1.900 | 1.145 | 3.150 | 0.849 | 1.045 | 0.660 | 1.655 |
| Higher T stage | <0.001 | 1.858 | 1.396 | 2.473 | 0.082 | 2.441 | 0.892 | 6.684 |
| Higher N stage | 0.002 | 1.635 | 1.199 | 2.228 | 0.043 | 1.944 | 1.023 | 3.697 |
| Higher TNM stage | <0.001 | 3.869 | 2.542 | 5.890 | 0.169 | 0.535 | 0.219 | 1.304 |
Data were presented as P value, HR (hazards ratio) and 95% CI (confidence interval). P value <0.05 was considered significant. Pathological grade was scored as 1-G1, 2-G2 and 3-G3; T stage was scored as 1-T1, 2-T2, 3-T3 and 4-T4; N stage was scored as 0-N0, 1-N1 and 2-N2; TNM stage was scored as 1-stage I, 2-stage II and 3-stage III; A Cox’s proportional hazards analysis was performed based on these definitions. OS: overall survival.