Table 2.
Cox-regression analysis of parameters associated with overall survival of all patients
| Factor | Univariate | Multivariate | ||
|---|---|---|---|---|
|
| ||||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | ||||
| ≤ 46 | Reference | |||
| > 46 | 1.019 (0.487-2.134) | 0.960 | - | - |
| Gender | ||||
| Male | Reference | |||
| Female | 1.160 (0.495-2.718) | 0.732 | - | - |
| Histology | ||||
| WHO I | ||||
| WHO II | Reference | - | - | |
| WHO III | 1.456 (0.700-3.027) | 0.315 | - | - |
| Clinical stage (UICC) | ||||
| I | Reference | 0.000 | Reference | 0.000 |
| II | 0.036 (0.006-0.221) | 0.000 | 0.020 (0.003-0.134) | 0.000 |
| III | 0.046 (0.009-0.239) | 0.000 | 0.018 (0.003-0.111) | 0.000 |
| IV | 0.147 (0.030-0.726) | 0.019 | 0.073 (0.013-0.397) | 0.002 |
| T classification | ||||
| T1 | Reference | 0.263 | ||
| T2 | 1.103 (0.360-3.377) | 0.863 | - | - |
| T3 | 0.546 (0.215-1.385) | 0.202 | - | - |
| T4 | 0.438 (0.152-1.263) | 0.126 | - | - |
| N classification | ||||
| N0 | Reference | 0.001 | ||
| N1 | 0.081 (0.021-0.316) | 0.000 | - | - |
| N2 | 0.237 (0.083-0.682) | 0.008 | - | - |
| N3 | 0.257 (0.100-0.660) | 0.005 | - | - |
| Carotid sheath involvement | ||||
| No | Reference | |||
| Yes | 0.903 (0.314-2.594) | 0.849 | - | - |
| Nasal cavity involvement | ||||
| No | Reference | |||
| Yes | 0.740 (0.344-1.593) | 0.441 | - | - |
| Maxillary sinus involvement | ||||
| No | Reference | |||
| Yes | 0.754 (0.334-1.702) | 0.496 | - | - |
| Neck lymph node level involvement | ||||
| No | Reference | 0.003 | ||
| Level I-III | 0.211 (0.026-1.723) | 0.147 | - | - |
| Level IV-V | 0.241 (0.094-0.617) | 0.003 | - | - |
| Maximum neck lymph node diameter | ||||
| <20 mm | Reference | Reference | ||
| ≥20 mm | 0.394 (0.179-0.865) | 0.020 | 0.378 (0.166-0.859) | 0.020 |
| ZIC2 expression | ||||
| Low | Reference | Reference | ||
| High | 0.219 (0.087-0.551) | 0.001 | 0.146 (0.054-0.399) | 0.000 |