Table 1.

Allele frequencies of candidates SNPs examined in IL-1 gene among cases and controls

SNP	Gene	Chr	Position	Allele	Minor allele frequency		HWE P value	OR (95% CI)	P a
					Case	Control
rs3783550	IL-1α	2q13	113532885	T/G	0.410	0.333	0.7956	1.39 (1.10-1.76)	0.021*
rs3783546	IL-1α	2q13	113534830	C/G	0.420	0.332	0.8963	1.46 (1.15-1.85)	0.006*
rs2856838	IL-1α	2q13	113539972	A/G	0.297	0.240	0.6332	1.34 (1.03-1.73)	0.040*
rs1609682	IL-1α	2q13	113540205	T/G	0.410	0.334	0.7957	1.38 (1.09-1.75)	0.022*
rs3783521	IL-1α	2q13	113543577	G/A	0.430	0.333	0.7956	1.51 (1.19-1.91)	0.002*
rs2853550	IL-1β	2q13	113587121	A/G	0.090	0.092	0.2923	0.98 (0.66-1.45)	0.308
rs1143643	IL-1β	2q13	113588302	C/T	0.527	0.470	0.7276	1.26 (1.00-1.58)	0.128
rs3136558	IL-1β	2q13	113591275	G/A	0.372	0.379	0.8057	0.97 (0.77-1.22)	0.928
rs1143630	IL-1β	2q13	113591655	T/G	0.162	0.155	0.5060	1.05 (0.77-1.43)	0.936
rs1143627	IL-1β	2q13	113594387	G/A	0.561	0.465	0.0470	1.47 (1.17-1.85)	< 0.001*
rs16944	IL-1β	2q13	113594867	A/G	0.561	0.455	0.0803	1.53 (1.22-1.92)	< 0.001*
rs1143623	IL-1β	2q13	113595829	G/C	0.487	0.373	0.0359	1.59 (1.26-2.00)	< 0.001*

SNP: Single nucleotide polymorphism; OR = Odds ratio; 95% CI = 95% confidence interval; HWE: Hardy-Weinberg equilibrium.

^* P < 0.05 indicates statistical significance;

^a P values were calculated using Pearson Chi-square test/Fisher’s exact test.