Table 2.
Relationship between IL-1 SNPs and tuberculosis risk under multiple models of analysis
| SNP | Model | Genotype | Control | Case | OR (95% CI) | P a |
|---|---|---|---|---|---|---|
| rs3783550 | Codominant | G/G | 132 (44.0%) | 101 (33.8%) | 1.00 | 0.020* |
| G/T | 136 (45.3%) | 151 (50.5%) | 1.45 (1.03-2.05) | |||
| T/T | 32 (10.7%) | 47 (15.7%) | 1.92 (1.14-3.22) | |||
| Dominant | G/G | 132 (44.0%) | 101 (33.8%) | 1.00 | 0.010* | |
| G/T+T/T | 168 (56.0%) | 198 (66.2%) | 1.54(1.11-2.14) | |||
| Recessive | G/G+G/T | 268 (89.3%) | 252 (84.3%) | 1.00 | 0.067 | |
| T/T | 32 (10.7%) | 47 (15.7%) | 1.56 (0.97-2.53) | |||
| Overdominant | G/G+T/T | 164 (54.7%) | 148 (49.5%) | 1.00 | 0.210 | |
| G/T | 136 (45.3%) | 151 (50.5%) | 1.23 (0.89-1.70) | |||
| Log-additive | --- | --- | --- | 1.40 (1.10-1.79) | 0.006* | |
| rs3783546 | Codominant | G/G | 132 (44.3%) | 95 (32.2%) | 1.00 | 0.006* |
| G/C | 134 (45.0%) | 152 (51.5%) | 1.58 (1.11-2.24) | |||
| C/C | 32 (10.7%) | 48 (16.3%) | 2.08 (1.24-3.5) | |||
| Dominant | G/G | 132 (44.3%) | 95 (32.2%) | 1.00 | 0.002* | |
| G/C+C/C | 166 (55.7%) | 200 (67.8%) | 1.67 (1.20-2.34) | |||
| Recessive | G/G+G/C | 266 (89.3%) | 247 (83.7%) | 1.00 | 0.048* | |
| C/C | 32 (10.7%) | 48 (16.3%) | 1.62 (1.00-2.61) | |||
| Overdominant | G/G+C/C | 164 (55.0%) | 143 (48.5%) | 1.00 | 0.110 | |
| G/C | 134 (45.0%) | 152 (51.5%) | 1.30 (0.94-1.80) | |||
| Log-additive | --- | --- | --- | 1.48 (1.16-1.88) | 0.001* | |
| rs2856838 | Codominant | G/G | 170 (57.0%) | 140 (46.7%) | 1.00 | 0.039* |
| A/G | 113 (37.9%) | 142 (47.3%) | 1.53 (1.09-2.13) | |||
| A/A | 15 (5.0%) | 18 (6.0%) | 1.46 (0.71-3.00) | |||
| Dominant | G/G | 170 (57.0%) | 140 (46.7%) | 1.00 | 0.011* | |
| A/G+A/A | 128 (43.0%) | 160 (53.3%) | 1.52 (1.10-2.10) | |||
| Recessive | G/G+A/G | 283 (95.0%) | 282 (94.0%) | 1.00 | 0.600 | |
| A/A | 15 (5.0%) | 18 (6.0%) | 1.46 (0.71-3.00) | |||
| Overdominant | G/G+A/A | 185 (62.1%) | 158 (52.7%) | 1.00 | 0.020* | |
| A/G | 113 (37.9%) | 142 (47.3%) | 1.47 (1.06-2.04) | |||
| Log-additive | --- | --- | --- | 1.37 (1.05-1.80) | 0.020* | |
| rs1609682 | Codominant | G/G | 131 (44.0%) | 101 (33.8%) | 1.00 | 0.022* |
| G/T | 135 (45.3%) | 151 (50.5%) | 1.45 (1.02-2.06) | |||
| T/T | 32 (10.7%) | 47 (15.7%) | 1.91 (1.13-3.20) | |||
| Dominant | G/G | 131 (44.0%) | 101 (33.8%) | 1.00 | 0.011* | |
| G/T+T/T | 167 (56.0%) | 198 (66.2%) | 1.54 (1.10-2.14) | |||
| Recessive | G/G+G/T | 266 (89.3%) | 252 (84.3%) | 1.00 | 0.072 | |
| T/T | 32 (10.7%) | 47 (15.7%) | 1.55 (0.96-2.51) | |||
| Overdominant | G/G+T/T | 163 (54.7%) | 148 (49.5%) | 1.00 | 0.200 | |
| G/T | 135 (45.3%) | 151 (50.5%) | 1.23 (0.89-1.70) | |||
| Log-additive | --- | --- | --- | 1.40 (1.10-1.78) | 0.006* | |
| rs3783521 | Codominant | A/A | 132 (44.0%) | 89 (30.4%) | 1.00 | 0.002* |
| A/G | 136 (45.3%) | 156 (53.2%) | 1.70 (1.19-2.42) | |||
| G/G | 32 (10.7%) | 48 (16.4%) | 2.22 (1.32-3.75) | |||
| Dominant | A/A | 132 (44.0%) | 89 (30.4%) | 1.00 | < 0.001* | |
| A/G+G/G | 168 (56.0%) | 204 (69.6%) | 1.80 (1.28-2.52) | |||
| Recessive | A/A+A/G | 268 (89.3%) | 245 (83.6%) | 1.00 | 0.041 | |
| G/G | 32 (10.7%) | 48 (16.4%) | 1.64 (1.02-2.65) | |||
| Overdominant | A/A+G/G | 164 (54.7%) | 137 (46.8%) | 1.00 | 0.054 | |
| A/G | 136 (45.3%) | 156 (53.2%) | 1.37 (0.99-1.9) | |||
| Log-additive | --- | --- | --- | 1.55 (1.21-1.97) | < 0.001* | |
| rs2853550 | Codominant | G/G | 248 (82.9%) | 254 (84.7%) | 1.00 | 0.300 |
| A/G | 47 (15.7%) | 38 (12.7%) | 0.79 (0.50-1.25) | |||
| A/A | 4 (1.3%) | 8 (2.7%) | 1.95 (0.58-6.57) | |||
| Dominant | G/G | 248 (82.9%) | 254 (84.7%) | 1.00 | 0.570 | |
| A/G+A/A | 51 (17.1%) | 46 (15.3%) | 0.88 (0.57-1.36) | |||
| Recessive | G/G+A/G | 295 (98.7%) | 292 (97.3%) | 1.00 | 0.240 | |
| A/A | 4 (1.3%) | 8 (2.7%) | 2.02 (0.60-6.78) | |||
| Overdominant | G/G+A/A | 252 (84.3%) | 262 (87.3%) | 1.00 | 0.280 | |
| A/G | 47 (15.7%) | 38 (12.7%) | 0.78 (0.49-1.23) | |||
| Log-additive | --- | --- | --- | 0.98 (0.68-1.42) | 0.910 | |
| rs1143643 | Codominant | T/T | 82 (27.4%) | 67 (22.6%) | 1.00 | 0.130 |
| T/C | 153 (51.2%) | 146 (49.3%) | 1.17 (0.79-1.73) | |||
| C/C | 64 (21.4%) | 83 (28.0%) | 1.59 (1.00-2.51) | |||
| Dominant | T/T | 82 (27.4%) | 67 (22.6%) | 1.00 | 0.180 | |
| T/C+C/C | 217 (72.6%) | 229 (77.4%) | 1.29 (0.89-1.87) | |||
| Recessive | T/T+T/C | 235 (78.6%) | 213 (72.0%) | 1.00 | 0.060 | |
| C/C | 64 (21.4%) | 83 (28.0%) | 1.43 (0.98-2.08) | |||
| Overdominant | T/T+C/C | 146 (48.8%) | 150 (50.7%) | 1.00 | 0.650 | |
| T/C | 153 (51.2%) | 146 (49.3%) | 0.93 (0.67-1.28) | |||
| Log-additive | --- | --- | --- | 1.26 (1.00-1.58) | 0.048* | |
| rs3136558 | Codominant | A/A | 116 (38.9%) | 118 (39.3%) | 1.00 | 0.930 |
| A/G | 138 (46.3%) | 141 (47.0%) | 1.00 (0.71-1.42) | |||
| G/G | 44 (14.8%) | 41 (13.7%) | 0.92 (0.56-1.51) | |||
| Dominant | A/A | 116 (38.9%) | 118 (39.3%) | 1.00 | 0.920 | |
| A/G+G/G | 182 (61.1%) | 182 (60.7%) | 0.98 (0.71-1.37) | |||
| Recessive | A/A+A/G | 254 (85.2%) | 259 (86.3%) | 1.00 | 0.700 | |
| G/G | 44 (14.8%) | 41 (13.7%) | 0.91 (0.58-1.45) | |||
| Overdominant | A/A+G/G | 160 (53.7%) | 159 (53.0%) | 1.00 | 0.870 | |
| A/G | 138 (46.3%) | 141 (47.0%) | 1.03 (0.75-1.42) | |||
| Log-additive | --- | --- | --- | 0.97 (0.77-1.22) | 0.790 | |
| rs1143630 | Codominant | G/G | 212 (70.7%) | 208 (69.3%) | 1.00 | 0.940 |
| G/T | 83 (27.7%) | 87 (29.0%) | 1.07 (0.75-1.53) | |||
| T/T | 5 (1.7%) | 5 (1.7%) | 1.02 (0.29-3.57) | |||
| Dominant | G/G | 212 (70.7%) | 208 (69.3%) | 1.00 | 0.720 | |
| G/T+T/T | 88 (29.3%) | 92 (30.7%) | 1.07 (0.75-1.51) | |||
| Recessive | G/G+G/T | 295 (98.3%) | 295 (98.3%) | 1.00 | 1.000 | |
| T/T | 5 (1.7%) | 5 (1.7%) | 1.00 (0.29-3.49) | |||
| Overdominant | G/G+T/T | 217 (72.3%) | 213 (71.0%) | 1.00 | 0.720 | |
| G/T | 83 (27.7%) | 87 (29.0%) | 1.07 (0.75-1.52) | |||
| Log-additive | --- | --- | --- | 1.05 (0.77-1.45) | 0.740 | |
| rs1143627 | Codominant | G/G | 55 (18.5%) | 96 (32.3%) | 1.00 | 5E-04* |
| A/G | 166 (55.9%) | 141 (47.5%) | 0.49 (0.33-0.73) | |||
| A/A | 76 (25.6%) | 60 (20.2%) | 0.45 (0.28-0.73) | |||
| Dominant | G/G | 55 (18.5%) | 96 (32.3%) | 1.00 | 1E-04* | |
| A/G+A/A | 242 (81.5%) | 201 (67.7%) | 0.48 (0.33-0.7) | |||
| Recessive | G/G+A/G | 221 (74.4%) | 237 (79.8%) | 1.00 | 0.120 | |
| A/A | 76 (25.6%) | 60 (20.2%) | 0.74 (0.50-1.08) | |||
| Overdominant | G/G+A/A | 131 (44.1%) | 156 (52.5%) | 1.00 | 0.040* | |
| A/G | 166 (55.9%) | 141 (47.5%) | 0.71 (0.52-0.99) | |||
| Log-additive | --- | --- | --- | 0.67 (0.53-0.85) | 7E-04* | |
| rs16944 | Codominant | A/A | 54 (18.0%) | 95 (32.1%) | 1.00 | 2E-04* |
| A/G | 165 (55.0%) | 142 (48.0%) | 0.49 (0.33-0.73) | |||
| G/G | 81 (27.0%) | 59 (19.9%) | 0.41 (0.26-0.66) | |||
| Dominant | A/A | 54 (18.0%) | 95 (32.1%) | 1.00 | 1E-04* | |
| A/G+G/G | 246 (82.0%) | 201 (67.9%) | 0.46 (0.32-0.68) | |||
| Recessive | A/A+A/G | 219 (73.0%) | 237 (80.1%) | 1.00 | 0.042* | |
| G/G | 81 (27.0%) | 59 (19.9%) | 0.67 (0.46-0.99) | |||
| Overdominant | A/A+G/G | 135 (45.0%) | 154 (52.0%) | 1.00 | 0.086 | |
| A/G | 165 (55.0%) | 142 (48.0%) | 0.75 (0.55-1.04) | |||
| Log-additive | --- | --- | --- | 0.64 (0.51-0.81) | 2E-04* | |
| rs1143623 | Codominant | C/C | 109 (36.3%) | 80 (26.7%) | 1.00 | 1E-04* |
| G/C | 158 (52.7%) | 148 (49.3%) | 1.28 (0.89-1.84) | |||
| G/G | 33 (11.0%) | 72 (24.0%) | 2.97 (1.80-4.92) | |||
| Dominant | C/C | 109 (36.3%) | 80 (26.7%) | 1.00 | 0.011* | |
| G/C+G/G | 191 (63.7%) | 220 (73.3%) | 1.57 (1.11-2.22) | |||
| Recessive | C/C+G/C | 267 (89.0%) | 228 (76.0%) | 1.00 | < 1E-04* | |
| G/G | 33 (11.0%) | 72 (24.0%) | 2.56 (1.63-4.00) | |||
| Overdominant | C/C+G/G | 142 (47.3%) | 152 (50.7%) | 1.00 | 0.410 | |
| G/C | 158 (52.7%) | 148 (49.3%) | 0.88 (0.64-1.21) | |||
| Log-additive | --- | --- | --- | 1.63 (1.29-2.08) | < 1E-04* |
SNPs: Single nucleotide polymorphisms; OR = odds ratio; 95% CI = 95% confidence interval.
*
P < 0.05 indicates statistical significance;
a
p values were calculated by unconditional logistic regression.