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Kaplan-Meier analysis of the overall survival of CRC patients with positive and negative expression of SphK1 (A), positive and negative expression of Cx43 (B), and the presence of VM (C). Log rank tests showed that SphK1 positivity (P = 0.0443) and the presence of VM (P = 0.0388) were significantly associated with poor survival, but Cx43 positivity (P = 0.7732) was not associated with survival.
