HIF-1α expression in HCT 116 xenograft or RKO xenograft and their corresponding normal colon tissues. Representative images for HE and IHC of HIF-1α for HCT 116 xenograft (A, B) or RKO xenograft and their corresponding normal colon tissues (F, G). IOD of HIF-1α in HCT 116 xenograft or RKO xenograft and their corresponding normal colon tissues (C, H). Western blot and statistical analysis of HIF-1α in HCT 116 xenograft (D, E) or RKO xenograft (I, J) and their corresponding normal colon tissues. N = 6 in each group. The group of blots was cropped from different gels. *P < 0.05 vs. corresponding normal colon.