Table 2.
Relationships between HIF-1α expression and clinicopathological characteristics in 92 colon adenocarcinoma cases
| Characteristics | HIF-1α expression (%) | p value | |
|---|---|---|---|
|
| |||
| Low | High | ||
| Total | 29 | 63 | |
| Average years | 61.3 ± 11.2 | 62.9 ± 12.3 | |
| < 65 | 17 (58.6) | 33 (52.4) | 0.655 |
| ≥ 65 | 12 (41.4) | 30 (47.6) | |
| Gender | |||
| Male | 21 (72.4) | 34 (54.0) | 0.113 |
| Female | 8 (27.6) | 29 (46.0) | |
| Histologic grade | |||
| I~II | 23 (79.3) | 47 (74.6) | 0.794 |
| II~III | 6 (20.7) | 16 (25.4) | |
| TNM stage | |||
| I-II | 22 (75.9) | 32 (50.8) | 0.025 |
| III-IV | 7 (24.1) | 31 (49.2) | |
| Location (cm) | |||
| Left colon | 11 (37.9) | 28 (44.4) | 0.652 |
| Right colon | 18 (62.1) | 35 (55.6) | |
| Infiltration degree | |||
| Adventitia | 19 (65.5) | 45 (71.4) | 0.629 |
| Serosa/muscular/mucosa | 10 (34.5) | 18 (28.6) | |
| Pathological morphology | |||
| Infiltrate/ulcer type | 20 (69.0) | 48 (76.2) | 0.458 |
| Protrude/basin type | 9 (31.0) | 15 (23.8) | |
| Distant metastasis and Vascular invasion | 2 (6.9) | 16 (25.4) | 0.048 |
| Positive lymph nodes | 7 (24.1) | 30 (47.6) | 0.041 |