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. 2019 Sep 17;7(4):433–440. doi: 10.1016/j.esxm.2019.08.005

Figure 5.

Figure 5

Phenotypic transformation and p-p38 in CCSMCs. Panel A shows the results of CCSMC identification presented by immunofluorescent staining in the 2 groups. Panel B shows the morphologic change of CCSMCs. In Panel C, compared with the normoxia group, α-SMA and p-p38 were decreased significantly in the hypoxia group, and collagen I and HIF-1α were increased significantly in the hypoxia group (mean ± standard deviation) (magnification ×100). Statistically significant (independent t test): α-SMA (P = .01); collagen I (P = .012); p-p38 MAPK (P = .024); HIF-1α (P = .04). α-SMA = α-smooth muscle actin; CCSMC = corpora cavernosum smooth muscle cell; HIF-1α = hypoxia-inducible factor-1α; MAPK = mitogen-activated protein kinase; p-p38 MAPK = phosphorylated p38 mitogen-activated protein kinase.