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Viral manipulation of SLAMF2 to evade host immunity. (A) Following infection, the CMV viral protein m154 proteolytically degrades SLAMF2 in order to decrease receptor expression on the cell surface. (B) Owl Monkey CMV produces a decoy SLAMF2 receptor following infection of a cell. The SLAMF2 decoy protein is secreted and, once soluble, prevents proper SLAMF2–SLAMF4 interactions from occurring between CMV infected cells and cytotoxic lymphocytes, respectively.
