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. 2019 Nov 12;8(4):231. doi: 10.3390/pathogens8040231

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ChAdOx1 Chik and ChAdOx1 Chik ΔCap vaccines prevent foot swelling of A129 mice following CHIKV-LR challenge. (a) Maximum foot thickness in millimeters (mm) at any given timepoint following CHIKV infection. Comparison between the control foot (right foot) and the CHIKV injected foot (left foot). Dots represent each mouse. Multiple paired two-tailed t-tests with Holm-Sidak; **** p < 0.0001. (b) Percentages of CHIKV-induced foot swelling compared to baseline (day 1 post injection). Data represented as means and SEMs. Restricted maximum likelihood mixed model with Dunnett’s (compared to PBS group); * p < 0.05; *** p < 0.001.

ChAdOx1 Chik and ChAdOx1 Chik ΔCap vaccines prevent foot swelling of A129 mice following CHIKV-LR challenge. (a) Maximum foot thickness in millimeters (mm) at any given timepoint following CHIKV infection. Comparison between the control foot (right foot) and the CHIKV injected foot (left foot). Dots represent each mouse. Multiple paired two-tailed t-tests with Holm-Sidak; **** p < 0.0001. (b) Percentages of CHIKV-induced foot swelling compared to baseline (day 1 post injection). Data represented as means and SEMs. Restricted maximum likelihood mixed model with Dunnett’s (compared to PBS group); * p < 0.05; *** p < 0.001.