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. 2019 Dec 9;3(23):4043–4049. doi: 10.1182/bloodadvances.2019000930

Table 3.

Characteristics of IFIs during VEN-HMA therapy

UPN Age, y/sex AML setting AML type Antifungal prophylaxis Response Prior alloHCT HMA regimen (d) Onset of IFI, d Diagnosis of IFI Fungal infection Site
1 77/M Untreated De novo None CR No Azacitidine (7) 281 Probable Aspergillus niger Lung
2 68/F r/r Therapy related Micafungin CR No Decitabine (5) 35 Proven Mucor Disseminated; lung, erector spinae muscles, liver and spleen.
3 75/M r/r De novo Fluconazole CRi No Decitabine (5) 104 Proven Rhizopus spp. Sinusitis and brain infarct
4 70/M r/r De novo Micafungin CRi No Azacitidine (7) 109 Probable and proven Aspergillus Mucor - 11/2018 developed on CRESEMBA then treated with AmBisome Lung liver/spleen, had splenectomy.
5 55/F r/r Secondary Posaconazole Refractory Yes Decitabine (5) 56 Proven Scedosporium prolificans Blood
6 62/M r/r De novo Micafungin Refractory No Decitabine (10) 92 Probable Aspergillus Lung
7 66/M Untreated De novo Micafungin (patient was being treated with ABELCET empirically when BALF from 8/9/2017 was positive for hyphae) Refractory No Decitabine (5) 61 Probable Unspecified mold infection Lung
8 57/M r/r Secondary Micafungin Refractory No Decitabine (10) 38 Probable Aspergillus Lung
9 45/M Untreated Therapy related Isavuconazonium Refractory No Decitabine (10) 71 Proven Rhizopus spp. Sinus/orbit
10 32/F r/r De novo Posaconazole Refractory Yes Decitabine (10) 73 Probable Aspergillus Lung
11 74/F r/r De novo None Refractory No Azacitidine (7) 60 Proven Scedosporium apiospermum Skin/deep tissue
12 71/F r/r Secondary Isavuconazonium Refractory No Azacitidine (7) 115 Probable Mucor Lung
13 56/F r/r De novo Posaconazole Refractory Yes Azacitidine (7) 59 Probable Aspergillus Lung
14 68/M r/r Secondary Isavuconazonium Refractory No Decitabine (5) 89 Proven Aspergillus fumigatus Lung
15 55/F r/r Therapy related Micafungin Refractory No Decitabine (10) 43 Probable Penicillium spp. Lung

BALF, bronchoalveolar lavage fluid; F, female; M, male; UPN, unique patient number.