Table 1.
Characteristics of patients treated with zoledronic acid (ZA) and placebo. Group differences between age, body mass index (BMI), and Modic changes (MC) volumes were analyzed using the t-test. Otherwise, the chi-square test was used.
| Variable | ZA | Placebo | p-Value |
|---|---|---|---|
| Age (years), mean (SD) | 49.2 (9.3) | 51.5 (7.3) | 0.400 |
| BMI (kg/m2), mean (SD) | 26.1 (3.3) | 27.4 (3.2) | 0.203 |
| Males, n (%) | 15 (75.0%) | 11 (55.0%) | 0.320 |
| Regular smoker, n (%) | 5 (25.0%) | 6 (30.0%) | >0.999 |
| Primary MC type, n (%) | 0.103 | ||
| MI | 3 (15.0%) | 3 (15.0%) | |
| MI/II-1 | 14 (70.0%) | 7 (35.0%) | |
| MI/II-2 | 2 (10.0%) | 8 (40.0%) | |
| MII | 1 (5.0%) | 2 (10.0%) | |
| Number of MCs, n (%) | 0.333 | ||
| 1 | 10 (50.0%) | 14 (70.0%) | |
| 2 or more | 10 (50%) | 6 (30.0%) | |
| Volume of primary MC, mean (SD) | |||
| Type 1 | 7443 (4474) | 5044 (3551) | 0.068 |
| Type 2 | 4542 (3897) | 5868 (4840) | 0.346 |
| Total | 11,985 (5140) | 10,911 (5963) | 0.546 |
| Osteoarthritis, n (%) | 1 (5.0%) | 6 (30.0%) | 0.091 |
| Back pain (VAS), mean (SD) | 6.6 (1.4) | 6.8 (1.6) | 0.646 |
| Leg pain (VAS), mean (SD) | 3.0 (3.1) | 2.9 (2.3) | 0.864 |
| Oswestry disability index, mean (SD) | 30.1 (11.0) | 34.9 (9.8) | 0.157 |