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. 2019 Dec 2;8(4):281. doi: 10.3390/pathogens8040281

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic diagram of bivalent influenza vaccine strain. (A) Construction of recombinant neuraminidase (NA) gene by insertion of a short-peptide from Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Spike (red color) in NA stalk region of H1N1pdm2009 forming chimeric bivalent construct. Abbreviations: (TM) trans-membrane domain, (NA) neuraminidase. (B) Schematic diagram for the reverse genetics (rg) process to generate a candidate chimeric bivalent 5 + 3 virus carrying small peptide as a bivalent vaccine against H1N1pdm09 and MERS-CoV.