Table 1.
Minimal inhibitory and bactericidal concentrations (MIC and MBC, respectively) of HybenX® sodium hypochlorite and chlorhexidine on a collection of Gram-negative and Gram-positive strains.
| Species | Sodium Hypochlorite (%) | Chlorhexidine (%) | Hybenx® (%) | |||
|---|---|---|---|---|---|---|
| MIC | MBC | MIC | MBC | MIC | MBC | |
| Pseudomonas aeruginosa PAO-1 | 1.6 × 10−1 | 3.0 × 10−1 | 7.8 × 10−4 | 6.3 × 10−3 | 3.9 × 10−1 | 3.9 × 10−1 |
| Pseudomonas aeruginosa ATCC 27853 | 1.6 × 10−1 | 3.0 × 10−1 | 1.5 × 10−3 | 3.1 × 10−3 | 3.9 × 10−1 | 3.9 × 10−1 |
| Staphylococcus aureus ATCC 29213 | 3.9 × 10−2 | 7.8 × 10−2 | 9.8 × 10−5 | 2.0 × 10−4 | 3.9 × 10−1 | 3.9 × 10−1 |
| Staphylococcus aureus ATCC 25923 | 3.9 × 10−2 | 7.8 × 10−2 | 4.9 × 10−5 | 9.8 × 10−5 | 3.9 × 10−1 | 7.8 × 10−1 |
| Staphylococcus aureus ATCC 33591 a | 3.9 × 10−2 | 7.8 × 10−2 | 9.8 × 10−5 | 2.0 × 10−4 | 3.9 × 10−1 | 3.9 × 10−1 |
| Enterococcus faecalis ATCC 29212 | 7.8 × 10−2 | 1.6 × 10−1 | 3.9 × 10−4 | 7.8 × 10−4 | 3.9 × 10−1 | 3.9 × 10−1 |
| Enterococcus faecalis 51299 b | 3.9 × 10−2 | 7.8 × 10−2 | 3.9 × 10−4 | 7.8 × 10−2 | 3.9 × 10−1 | 7.8 × 10−1 |
| Escherichia coli ATCC 25922 | 3.9 × 10−2 | 7.8 × 10−2 | 4.9 × 10−5 | 4.9 × 10−5 | 3.9 × 10−1 | 3.9 × 10−1 |
| Escherichia coli NCTC 13476 c | 7.8 × 10−2 | 1.6 × 10−1 | 3.9 × 10−4 | 3.9 × 10−4 | 3.9 × 10−1 | 3.9 × 10−1 |
| Escherichia coli ATCC 35218 | 3.9 × 10−2 | 7.8 × 10−2 | 9.8 × 10−5 | 2.0 × 10−4 | 3.9 × 10−1 | 3.9 × 10−1 |
| Klebsiella pneumoniae ATCC 700603 d | 7.8 × 10−2 | 1.6 × 10−1 | 6.3 × 10−3 | 1.3 × 10−2 | 3.9 × 10−1 | 7.8 × 10−1 |
| Klebsiella pneumoniae ATCC 13883 | 7.8 × 10−2 | 1.6 × 10−1 | 1.6 × 10−3 | 3.0 × 10−3 | 3.9 × 10−1 | 3.9 × 10−1 |
| Klebsiella pneumoniae CIP 52.145 e | 7.8 × 10−2 | 1.6 × 10−1 | 3.1 × 10−3 | 6.0 × 10−3 | 3.9 × 10−1 | 3.9 × 10−1 |
| Acinetobacter baumannii ATCC 17978 | 3.9 × 10−2 | 7.8 × 10−2 | 1.5 × 10−3 | 3.0 × 10−3 | 3.9 × 10−1 | 3.9 × 10−1 |
| Enterobacter cloacae ATCC 13047 | 7.8 × 10−2 | 1.6 × 10−1 | 1.9 × 10−4 | 3.9 × 10−4 | 3.9 × 10−1 | 3.9 × 10−1 |
| Klebsiella aerogenes ATCC 13048 | 7.8 × 10−2 | 1.6 × 10−1 | 6.3 × 10−3 | 1.3 × 10−2 | 3.9 × 10−1 | 3.9 × 10−1 |
a MRSA: methicillin-resistant Staphylococcus aureus; b VRE: vancomycin-resistant Enterococcus; c CPE: carbapenemase-producing Enterobacterales; d ESBL: extended-spectrum β-lactamase producer; e strain showing an hypermucoviscous phenotype.