Table 1.
CASS summary of the six gonococcal candidate antigens.
| Candidate | mRNA Expression In Vivo (RPKM) | PREDICTED | Core Genome 5 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Antigen Score 1 | Localization 2 | Structure 3 | Function 4 | ||||||||
| TM Domain | Signal Sequence | Size (kDa) | Annotation/Homology | ||||||||
| NGO0416 | 196 | 127 | 0.5 | P, non-cytosol |
0 | SP | 10.8 | hypothetical | NEIS0782NMB0844 | yes | |
| NGO0690 | 142 | 157 | 0.7 | P/OM, non-cytosol |
1 | LP | 12.1 | hypothetical, lipoprotein |
NEIS1164NMB1047 | yes | |
| NGO0948 | 125 | 105 | 0.43 | P/OM, non-cytosol |
0 | - | 44.8 | lipoprotein, NlpB/DapX/BamC |
NEIS0906NMB0928 | yes | |
| NGO1043 | 1748 | 519 | 0.82 | P/OM, non-cytosol |
0 | LP | 10.2 | hypothetical, lipoprotein |
NEIS2446NMB1468 | yes | |
| NGO1215 | 190 | 292 | 0.67 | P, non-cytosol |
0 | SP | 16.1 | hypothetical, PCu(A)C/, AccA |
NEIS1474NMB1557 | yes | |
| NGO1701 | 127 | 121 | 0.41 | P, non-cytosol |
0 | SP | 14.4 | membrane, TAT_Cys_rich four helix bundle copper-binding protein |
NEIS2720 | yes | |
1 VaxiJen; 2 PSORTb, PredictProt, Gneg-mPLoc, Phobius; 3 TMHMM, SignalP, LipoP; 4 BLASTp, UniProtKB, PFAM, KEGG, PubMLST, Vaxign; 5 PubMLST.