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. 2019 Nov 2;9(4):173. doi: 10.3390/diagnostics9040173

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Boxplots showing the mRNA levels of (a) TOP2A; (b) MKI67; (c) CDKN2A/p16 in the different diagnostic groups. Patients were grouped into three categories according to the cytological, histological, and virological results. These categories included: (a) Negative (negative Pap test result and negative high-risk human papillomavirus [HPV] test); (b) low-grade squamous intraepithelial lesion (LSIL) (Pap test result of LSIL and biopsy showing anal intraepithelial neoplasia grade 1 [LSIL/AIN1]); and (c) high-grade squamous intraepithelial lesion (HSIL) (patients with Pap test result of HSIL and biopsy confirming HSIL/AIN2–3). The values shown are expressed as ΔΔCt [(cycle threshold target-cycle threshold reference sample) − (cycle threshold SiHa-cycle threshold reference SiHa)]. The black line within the box represents the median; the whiskers represent the minimum and maximum values that lie within 1.5 interquartile ranges from the end of the box. Values outside this range are represented by black dots.

Boxplots showing the mRNA levels of (a) TOP2A; (b) MKI67; (c) CDKN2A/p16 in the different diagnostic groups. Patients were grouped into three categories according to the cytological, histological, and virological results. These categories included: (a) Negative (negative Pap test result and negative high-risk human papillomavirus [HPV] test); (b) low-grade squamous intraepithelial lesion (LSIL) (Pap test result of LSIL and biopsy showing anal intraepithelial neoplasia grade 1 [LSIL/AIN1]); and (c) high-grade squamous intraepithelial lesion (HSIL) (patients with Pap test result of HSIL and biopsy confirming HSIL/AIN2–3). The values shown are expressed as ΔΔCt [(cycle threshold target-cycle threshold reference sample) − (cycle threshold SiHa-cycle threshold reference SiHa)]. The black line within the box represents the median; the whiskers represent the minimum and maximum values that lie within 1.5 interquartile ranges from the end of the box. Values outside this range are represented by black dots.