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. 2019 Nov 21;8(12):533. doi: 10.3390/plants8120533

Figure 1.

Figure 1

AtTwinkle is a homolog of bacteriophage T7 primase-helicase and mitochondrial Twinkle. (A) Schematic representation of the bifunctional T7 primase-helicase in comparison to AtTwinkle and human Twinkle. T7 primase-helicase and AtTwinkle contain the conserved motifs necessary for primase and helicase activities, whereas human Twinkle is inactive as a primase. (B) Homology model of AtTwinkle showing its RNA polymerase domain and helicase modules with basis on the crystal structure of the heptameric T7 primase-helicase [31]. (C) Close view of a monomeric module of the RNAP and helicase of AtTwinkle. (D) Close view of the primase module composed of the zinc binding domain (ZBD) and RNAP domain. The conserved cysteines that coordinate the zinc atom are colored in red and magenta.