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. 2019 Oct 11;8(4):182. doi: 10.3390/antibiotics8040182

Table 3.

Impact of Different Antibiotics on S. aureus Biofilm Support of Phage Virion Production 1.

Antibiotic Log Δ PFUs with 0× MIC Log Δ PFUs with 2× MIC Log Δ PFUs with 10× MIC
Ciprofloxacin 2 <2 0
Daptomycin 2 >1 1
Erythromycin 2 <1 −3
Gentamycin 2 0 −4
Linezolid 2 <1 −3
Oxacillin 2 2 1
Rifampin 2 <2 <0
Tetracycline 2 1 <0
Vancomycin 2 1 0

1 Given simultaneous phage-antibiotic addition, as derived from the results of Dickey and Perrot [34], shown are estimated log change in phage titers within experiments (Log Δ PFUs). For example, 0 indicates no change, 2 indicates a 100-fold increase (thereby indicating phage population growth), −4 indicates a 10,000-fold decrease (the latter presumably because phages adsorbed to bacteria either immediately prior to or following bacterial death). For increased clarity, all numbers are approximations as obtained predominantly from their Figure 3. Roughly, values of 1 or more are indicative of at least moderately robust phage population growth.