Table 1.
Patient’s demographics.
| Contents | n = 177 Patients | Patients Collected between 2014–2016 |
p Value |
|---|---|---|---|
| Subgroup | LTS = 30 | STS = 147 | |
| Sex | Male n = 20–66.7% Female n = 10–33.3% |
Male n = 78, 53.06% Female n = 69, 46.93% |
0.128 |
| Age | 59.4 ± 7.69 | 61.16 ± 11.55 | 0.409 |
| KPS at admission | 89.0 ± 13.70 | 80.4 ± 12.41 | 0.010 |
| Volume in cm3 | 24.2 ± 19.3 | 22.22 ± 18.4 | 0.676 |
| Ki67 (%) | 18.7 ± 10.9 | 26.4 ± 15.4 | 0.061 |
| IDH Mutation status available in 166/177 pts | IDH Mutant 2/166 (6.7%) | IDH Mutant 0/166 | 0.027 |
| EGFR overexpression status available in 149/177 pts | EGFR Overexpressed 9/26 (34.6%) |
EGFR Overexpressed 35/124 (28.2%) |
0. 333 |
| MGMT Methylation status available in 53/177 | MGMT Methylated 17 patients | MGMT Methylated 8 patients | 0.397 |
| p53Mutation status available in 150/177 pts | Mutant p53 Normal 18/27 (66.7%) |
Mutant p53 66/124 (53.22%) |
0.144 |
| EOR | GTR 28/30patients (93.3%) STR 2/30 patients (6.7%) |
GTR 133/147 patients (90.80%) STR 14/147 patients (9.20%) |
0.468 |
| KPS after Surgery | 81.0 ± 25.11 | 73.9 ± 19.9 | 0.163 |
| KPS at last Evaluation | 39.5 ± 15.8 | 37.9 ± 17.6 | 0.721 |
| Overall Survival | 26.68 ± 7.1 months | 10.8±4.8 months | 0.001 |
| Location | Frontal 14 (46.6%) | Frontal 47 (31.9%) | 0.314 |
| Temporal 11 (36.6%) | Temporal 39 (26.5%) | ||
| Occipital 4 (13.3%) | Occipital 13 (8.8%) | ||
| Parietal 4 (13.3%) | Parietal 34 (23.1%) | ||
| Insular 2 (6.7%) | Insular 8 (5.44%) | ||
| Rolandic 2 (6.7%) | Rolandic 1 (0.7%) | ||
| Corpus Callosum 0 (0.0%) | Corpus Callosum 5 (3.4%) | ||
| Side | Left 18 (60.0%) | Left 69 (46.9%) | 0.743 |
| Right 12 (20.0%) | Right 66 (44.8%) | ||
| Midline 0 (0.0%) | Midline 8 (5.44%) | ||
| Multifocal 0 (0.0%) | Multifocal 1 (0.7%) | ||
| Symptoms | Headache 8 (26.6%) | Headache 25 (17.1%) | 0.115 |
| Seizures 8 (26.6%) | Seizures 41 (27.9%) | 0.544 | |
| Speech Disturbance 0 (0.0%) | Speech Disturbance 27 (18.4%) | 0.531 | |
| Motor Dysfunction 5 (16.6%) | Motor Dysfunction 35 (23.8%) | 0.491 | |
| Sensory Disturbance 6 (20.0%) | Sensory Disturbance 21(14.3%) | 0.600 | |
| Visual Deficit 1 (3.3%) | Visual Deficit 5 (3.4%) | 0.423 | |
| Incidental 2 (6.7%) | Incidental 4 (2.7%) | 0.384 |
PFS: Progression Free Survival; OS: Overall Survival; SVZ: Subventricular Zone, KPS: Karnofsky performance status, EOR: Extent of Resection, GTR: Gross Total Resection, NTR/STR: Near Total/Subtotal Resection.