Skip to main content
. 2020 Jan 16;27(1):83–93.e9. doi: 10.1016/j.chembiol.2019.11.007

Figure 4.

Figure 4

Structural Comparison of Different HOIP Conformations

(A) Structural comparison of the HOIP RBR domain from the dAb3 complex structure (in teal) with one of the RBR monomers from the HOIP RBR/UbcH5B-Ub structure (PDB: 5EDV, in blue), overlapped via the IBR domain. The dAb3 dimer is shown in transparent gray. The catalytic cysteine is shown in magenta as sticks and Zn2+ ions are shown as gray spheres.

(B) Structural comparison of the HOIP RBR domain from the dAb3 complex structure (in teal) with one of the RBR monomers from the HOIP RBR/UbcH5B-Ub structure (PDB: 5EDV, in blue), overlapped via the RING1 domain. The UbcH5B-Ub conjugate bound to RING1 is shown in pink and yellow. The catalytic cysteine is shown in magenta as sticks and Zn2+ ions are shown as gray spheres.